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====FYI: Literaturliste Grafik und Gestaltung====
==== Biologie für Fortgeschrittene ====
http://web.uni-weimar.de/medien/wiki/GMU:Die_neue_U-Bahn#Literatur
[http://www.youtube.com/watch?v=AkMdZPsM4No&feature=related Legostein 13] Legoanimation.
 
--[[User:Sebastian|sebastian]] 11:59, 22 September 2010 (CEST)
----
 
==== cells.de - Der Onlinedienst zur Zellbiologie mit Videos und interaktiven Medien ====
http://www.cells.de/cellsger/index.jsp
<br>
--[[User:Sebastian|sebastian]] 21:31, 2 September 2010 (CEST)
----
 
 
==== Interesting Reading: '''Das  Buch  des  Lebens''' ====
"Das  Buch  des  Lebens: wer  schrieb  den  genetischen  Code?" von Lily  E. Kay.
ISBN 3-518-29346-X
 
Recommended by [[User:Felixsattler|Felix Sattler]]<br>
--[[User:Sebastian|sebastian]] 19:44, 2 September 2010 (CEST)
 
----
 
==== Bio:Fiction Filmfestival about Synthetic Biology - !!DEADLINE EXTENDED!! ====
The new deadline will be ''December 1st 2010!'' [http://www.bio-fiction.com/Home.html Hurry up!]
 
--[[User:Sebastian|sebastian]] 15:28, 22 July 2010 (UTC)
 
----
 
====iGEM: Preliminary Project Descriptions Due====
 
As the iGEM [http://2010.igem.org/Calendar_of_Events calender of events] shows the [http://2010.igem.org/Preliminary_Project_Description preliminary project description] is due on 16. of july.
Please do not forget to take care of that.
 
--[[User:Sebastian|sebastian]] 17:54, 7 July 2010 (UTC)
 
----
 
===="Wir wissen nichts"====
[http://www.spiegel.de/spiegel/0,1518,703085,00.html Spiegel Interview] with Craig Venter
 
--[[User:Sebastian|sebastian]] 10:43, 5 July 2010 (UTC)
 
----
 
==== Marke.6 layout====
I have uploaded the newest version layout of Marke.6 application in dropbox. <br/>
But Mila said she didn't see it. So I upload it to wiki now. [http://web.uni-weimar.de/medien/wiki/File:Marke.6_layout4.pdf here is it!]<br/>
 
--[[User:Sharklu|Sharklu]] 21:37, 4 July 2010 (UTC) Lu Jiayuan
 
----
==== Artifacts from the future (Wired)====
In each issue of Wired magazine, at the end of the book, there’s a page called “artifact from the future” that consists in a heavily photoshopped photo of an object supposedly common in the future. These visual elements depicts designers, researchers, pundits’ prognostications about how the world “will look like in 10, 20 or 100 years“. Yes, it’s “will” not “may”, as shown in this article. See some examples systematically listed by sceptycal futurist [http://futuryst.blogspot.com/2008/03/compleat-wired-future-artifacts-gallery.html Stuart Candy]
 
 
--[[User:Bernd|Bernd]] 19:45, 2 July 2010 (UTC)
 
----
==== Knockout Moss====
 
There is also some more information about the moss on Prof. Dr. Ralf Reski's homepage of University Freiburg:
 
http://www.plant-biotech.net/
 
Yeah and the best about this moss is....you can order it!!!
 
At the university of freiburg international moss stock center:
 
http://www.moss-stock-center.org/
 
And that only for 50€ per mutant knock-out plant and only 5€ for the ecotype physcomitrella patens moss!
ah yeah plus shipping!
 
--[[User:Wawa|Wawa]] 13:52, 30 June 2010 (UTC)
 
In co-operation with the chemical company BASF Ralf Reski and coworkers established a collection of knockout mosses that is used for gene identification
last passage here:
 
[[wikipedia:de:Knockout Moss]]
 
 
 
--[[User:Bernd|Bernd]] 19:45, 2 July 2010 (UTC)
----
==== Epigenetics ====
[http://video.google.com/videoplay?docid=1128045835761675934#/The Ghost in your genes]
 
 
 
----
==== DIY Bio: Open Gel Box 2.0 ====
 
A DIY Gel electrophoresis box
from [http://www.pearlbiotech.com/ Pearl Biotech]
 
see also [http://openwetware.org/wiki/DIYbio:Notebook/Open_Gel_Box_2.0 here].
 
 
 
--[[User:Sebastian|sebastian]] 15:16, 23 June 2010 (UTC)
----
 
==== Cellularity====
<videoflash type=vimeo>10274649|600|340</videoflash>
 
The central idea behind this scenario is that we might one day understand life, not as a hard-edged category, but as a graduated scale between nonliving and living things. Each developmental stage in chemical cell biology is slightly more alive than the stage before. To formalize this idea, I designed a speculative definition of life named the “Cellularity Scale” which shows how five different living properties accumulate at each subsequent stage. Of course, this is a purely speculative definition of life, consistent with the scenario I have designed. If the Chell project or any of the several other bottom-up attempts at abiogenesis are successful, they will quite possibly offer an entirely different picture.
 
[http://www.james-king.net/projects/cellularity James King]
James' [http://seedmagazine.com/content/article/slippery_cellularities/ article] on Seedmagazine.com
 
 
 
--[[User:Bernd|Bernd]] 15:35, 22 June 2010 (UTC)
 
----
 
==== AI Game====
Just found on the c't magazine: [http://antme.net/description.html antme],a software simulating ants which behave according to an artificial intelligence. The AI needs to be coded beforehand. The project is aimed to C# beginners to teach programming. I see some parallels to our bacteria-game: we "code" DNA, it takes place in a closed environment etc.
 
 
 
----
==== Game and iGEM Project 2008 ====
 
Just a first, (finally not so) brief comment on the idea of making a kind of computer game, but with genetically modified bacteria. As some of you might already know, the iGEM project of our team in 2008 was about creating an artificial preditor-prey system by genetically modifying bacteria. We wanted therefore to create bacteria that would:<br/>
 
a) swim towards a target bacteria <br/>
b) kill that target bacteria when it would reach it<br/>
 
The second part (killing) worked really good, but the first part (swimming towards a certain target) didn't work out so good.
But anyway, there are interesting implications in both parts I want to comment on.
<br/><br/>
'''''a) making bacteria swim in a certain direction'''''<br/>
It is pretty well known in literature, that bacteria have certain so-called chemotaxis receptors [http://2008.igem.org/Team:Heidelberg/Project/Sensing] on their surface. These receptors are, in nature, used for recognizing attractand molecules (nutrition, i.e. sugar) or repellents (i.e. toxic molecules).
It is possible to influence (I would not say control, but at least strongly influence) the direction in that bacterial colonies on an agar plate swim by putting repellent and attractand molecules at different points on the plate. To give you one example: If I would put aspartate in the middle of an agar plate with E. coli colonies on it, the E. coli would move in direction of the aspartate. Their are different E. coli strains, that do contain different chemotaxis receptors or even no receptors. Furthermore, there are bacteria that swim fast, slow or bacteria that can't even swim at all. Find a comparisn of swimming and not-swimming bacteria [http://parts.mit.edu/igem07/images/f/f3/SwarmingPic.jpg here].
In general that could be interesting if you wanted to make bacteria swim toward each other. To give you an impression on what swimming bacteria on a plate would look like, here some examples from my bachelor thesis [[media:Bacheloararbeit_Dominik_Niopek_druck.pdf]]. In the 'center' assays, I just put bacteria on either site of the plate. As you can see, the swim rings of the two bacterial colonies meet in the middle after 24 hours (even faster, ie. 6 or 12 hours, depends on the bacteria). In the 'centerline' assay I spottet immobilized bacteria in one line in the middle, and mobile bacteria again on either site of the line.
 
Those so called swarm assays or swarm agar plates are really simple to prepare, easy to use. If you used different bacteria expressing color pigments (red, green, black), I am sure you could see how one bacteria would take over the space of the others, mix up with them, kill them etc.
<br/><br/>
'''''b) making bacteria kill other bacteria'''''<br/>
In 2008 we also developed a killing mechanism which worked pretty good. The principle is the following: One bacterial strain was engineered to secrete a certain messenger molecule, called Autoinducer-1. The other bacterial strain was engineered to recognize Autoinducer-1 and thereby activate the production of a bacterial toxin called colicin [http://2008.igem.org/Team:Heidelberg/Project/Killing_II]. This means: If both bacterial strains are nearby each other, the one would start to kill the other. It is no problem to label one bacterial strain in red and the other in green and to visualize how the green bacteria die if they are nearby the red ones under a microscope (figure 17 again on [http://2008.igem.org/Team:Heidelberg/Project/Killing_II this] page). The same should also be possible on swarm agar plates.
<br/>
With swimming bacteria on swarm agar plates, you have many options to play around, as their are so many different bacterial strains (swimming slower, faster, not at all, recognizing substances etc.). Take this just as some general comments to think about. In case their is something in that comments, that interests you in particular, please don't hesitate to shoot me an e-mail (d.niopek@gmx.de) or call me (01577-4054784). As I did my bachelor thesis on this topic (swimming bacteria), I would be very happy to provide you with all necessary information and help.
<br/><br/>
 
 
--[[User:Dniopek|Dniopek]] 23:18, 9 June 2010 (UTC)
----
====Go with the flow====
[[File:Flow-game-screenshot-4.jpg]]
 
I found a very interessting game over the internet.
It's a MFA thesis project from 'thatgamecompany'
and called 'flow'.
 
The game is about a small organism flowing through a watery atmosphere while consuming other small organisms.
Through consuming you as a player can evolve the abilities and appearance of your organism.
 
[http://thatgamecompany.com/about/ 'Thatgamecompany'] is a small colloboration
of game designers which working only with experimental games like 'flow'.
 
Everything is mostly about gaining new experiences and inspiring their players
via special sound and atmosphere....and without words!
 
 
 
--[[User:Wawa|Wawa]] 22:14, 9 June 2010 (UTC)
----
====Horror Movie about a Human-Animal Synbio Hybrid====
 
There is a movie playing in cinemas in germany at the moment about a synthetically created human-animal monster.
 
It is rather silly and acutally the name "Splice" is scientifically completely incorrect, but if you like to check it out, I'm sure it's worth a laugh (now that you know more about genetics than the average person)
 
Here's a wikipedia link [[wikipedia:Splice (film)]
 
Enjoy!
 
 
 
--[[User:Laura iGem|Laura iGem]] 17:51, 9 June 2010 (UTC)
====BioArts in Austrian Magazine====
 
An Austrian magazine for genome research, "Genosphären", is running an issue on BioArts and Synthetic Biology this month [http://www.gen-au.at/artikel.jsp?id=932&base=vermitteln&lang=de]. Since you probably won't get your hands on it, here is a round-up of artists that I could not find on your link-list yet. I am sorry if this is somehow redundant in case I missed blog entries, I tried to search through all of them.
 
- Jun Takita [http://juntakita.com/eng/home.html] created a model of his brain and planted transgenic moss on it. This moss can glow in the dark due to the Luciferase-Gene. This resembles the complex signals that occur in the brain.
 
- Gary Schneider, who takes genetic portraits of people (which is admittedly not the most original thing to do) [http://garyschneider.net/Portfolio.cfm?nK=7856]
 
- Adam Brandejs, who presented his sci-fi product, "Genpets", on a website disguised as a normal webshop and raised some outrage with his anti-allergic perfect pet. [http://www.genpets.com]
 
- Karsten Panzer, who created a colour-coding for the visiual sensation of genetic information [http://www.perzan.de]
 
I hope this gives some inspiration!
 
 
 
--[[User:Laura iGem|Laura iGem]] 17:35, 6 June 2010 (UTC)
----
====Zeit Artikel====
Synthetische Biologie -Leben 2.0<br />
Was passiert, wenn es der Bio-Industrie gelingt, den menschlichen Körper neu zu programmieren
* http://www.zeit.de/2010/23/Schoepfungsphantasien
 
 
--[[User:Max|max]] 18:00, 5 June 2010 (UTC)
----
====The Procreative Dinner====
An ephemeral work between art, science and gastronomy. Happening by Prune. Nice way of bringing people in touch with the topic...and another example of a collabortation of art and science.
* http://www.prune-art.com/blog/en/index.php?menu_id=1
 
 
 
--[[User:Mila|Mila]] 14:20, 3 June 2010 (UTC)
----
====Six part Series "Synthetische Biologie" on D-Radio====
[http://www.dradio.de/dlf/sendungen/forschak/1077533/ Schwerpunkt Synthetische Biologie]<br>
 
 
 
--[[User:Bernd|Bernd]] 09:19, 3 June 2010 (UTC)
----
====More Photos====
 
I have uploaded some photos which I took during the retreat.<br/> Enjoy [[GMU:Synthetic_Biology/Retreat|it]].!<br/>
 
 
 
--[[User:Sharklu|Sharklu]] 00:36, 2 June 2010 (UTC)Lu Jiayuan
----
====Back from the retreat====
 
The firs images of our lab experiences in Hedeilberg and our fruitful retreat to Asselheim can be found [[GMU:Synthetic_Biology/Retreat|here]]. Please feel free to add more pictures!
 
 
 
--[[User:Sebastian|sebastian]] 16:57, 1 June 2010 (UTC)
----
====Richard Jones' comment on Craig Venters successful insertion of a synthetic genome into a bacteria====
 
"One might almost suspect that there is a symbiosis going on here, between those scientists anxious to maximise the significance of their work, and bioethicists in search of an issue to raise their own profile. After all, if a piece of science is worth worrying about, it must be important. It’s not that I don’t think that these developments have potentially important societal and ethical implications – but it seems to me that these would be better considered from a standpoint that was a little more critical." Richard Jones on his [http://www.softmachines.org/wordpress/ Blog].
 
 
 
--[[User:Sebastian|sebastian]] 16:10, 26 May 2010 (UTC)
====First human 'infected with computer virus'====
[http://news.bbc.co.uk/2/hi/technology/10158517.stm Article] on BBC News
<br>
 
 
 
--[[User:Sebastian|sebastian]] 15:43, 26 May 2010 (UTC)
----
====A New Plant====
Hello! Everyone!
 
I have built my project page...<br/>
[[GMU:Synthetic_Biology/a new plant| a new plant]]<br/>
Welcome to do something!<br/>--
 
 
 
[[User:Sharklu|Sharklu]] 16:51, 24 May 2010 (UTC)<br/>
----
====To live, to err, to fall, to triumph, to recreate life out of life – the most pretentious bacterium ever====
 
''I'd create an animal that excretes meat, just to give vegetarians pause for thought. Ethically, what's the problem with eating a sausage, if it's been harmlessly pooed out by an animal? To sweeten the pill yet further, what if you put pleasure receptors in the animal's colon, so it actively enjoys the sausage-creation process – enjoys it to such a degree that it chases you down the street, yelping in orgasmic delight and producing a string of pan-ready chipolatas? If you think that's disgusting, I'd just like to point out that it's far less revolting than killing a pig with a bolt gun then mashing it up into sausagemeat.'' [http://www.guardian.co.uk/commentisfree/2010/may/24/charlie-brooker-artificial-life-here Charlie Brooker: So, artificial life is here, courtesy of Craig Venter. Time to remix humankind…]
 
 
 
--[[User:Bernd|Bernd]] 11:43, 24 May 2010 (UTC)
 
----
 
====Some more links on synthetic life====
[http://www.newscientist.com/article/dn18942-immaculate-creation-birth-of-the-first-synthetic-cell.html Newscienist: Immaculate creation: birth of the first synthetic cell]
 
[http://www.nytimes.com/2010/05/21/science/21cell.html?ref=science NYTimes: Researchers Say They Created a ‘Synthetic Cell’]
 
 
 
--[[User:Bernd|Bernd]] 09:17, 24 May 2010 (UTC)
----
 
===='''<span style="color:#2F4F4F">Kokoromo : My project is online====
 
So I also put up my project...
[[GMU:Synthetic_Biology/ko_ko_ro_mo| ko_ko_ro_mo]]
 
Please don't be shy and have a look.
 
I really look forward to discuss it with you all.
 
--[[User:Wawa|Wawa]] 23:18, 22 May 2010 (UTC)
----
 
====Response to 'My Flower'====
 
First response is written ^^
 
Have fun!
 
--[[User:Wawa|Wawa]] 15:51, 22 May 2010 (UTC)
 
====Update on my page====
Hello everybody.<br/>
There is new content on my project page.<br/>
It's about my ideas of improving my project.<br/>
The link is below:<br/>
*[[GMU:Synthetic_Biology/My Flower| My Flower]]
 
Please visit and leave comment!<br/>
Thanks!
 
--[[User:yuxiaorui|Yu Xiaorui]] 12:02, 22 May 2010 (UTC)
----
 
====Pass the impossimpleble :)====
Oh my! Are they already this far in development?
 
I found a pretty amazing TV documentation-series,
(if you can call like that...because its more a idealistic utopia),
of the berlin TVchannel Phoenix.
It is about the possibilities which may occur while living in future with new technologies. It think it would be very interessting for some of you.
 
To my shame it is only in german at the moment,
but under the link you can find some informations to the technolgies and the scientists.
 
 
 
[http://www.youtube.com/watch?v=NoVS_HvgFfw&feature=PlayList&p=C62483CC011D4E91&playnext_from=PL&playnext=1&index=18] Here comes part 1 of 3
 
First Episode - Living in the future - Humans
 
* houses and also clothes will be connected to the internet to control our health und living status every single moment electronic fibre by Dr. Prof. Sundaresan Jayaraman (Georgie Institute of Technology)
* cars will fly in the air with a satelite electronical guide system to provied us from traffic jams and accidents flying car by Dr. Paul Moller (Moller International)
* stemcells can be used to create new organs tissue engineering by Dr. Stefan Jockenhövel (Helmholz-Institute for biomedical technique)
* 3D genomic printer to create organs layer by layer by Dr. Prof. Thomas Boland (Clemson University)
* food wont make us fat anymore because of genetic engineered proteins by Dr. Prof. Med. Rob Hammer (Wageningen Centre of Food Science)
* cure paraplegia or other neural-muscular deseases with electronic sensor body-implants you can control with your thoughts sensors by Prof. Dr. John Donoghue (Brown University)
* computer surgery sytems controlled by doctors for precise working and without viral infections by Dr. Oliver Burgert (innovation-centre for computer-assisted surgery)
 
 
But all that glitters is not gold? Or?
 
Here also a small outlook what may happend with our health system in future.
Also german *yeah I know I know thats stupid*.
 
[http://www.ardmediathek.de/ard/servlet/content/3517136?documentId=3961048]
It is called: 'Leichen im Keller' or like the englisch proverb 'scelletons in the (closet) cellar'
 
I think it is rather nice^^
 
I look foward to have some smalltalk about the chances and risks of synbio with you all.
 
--[[User:Wawa|Wawa]] 18:29, 21 May 2010 (UTC)
----
 
====Its done====
How does it feel to have created artificial life, Dr Venter?
 
http://www.independent.co.uk/news/people/profiles/dr-craig-venter-so-doctor-how-does-it-feel-to-have-created-artificial-life-1978873.html
 
http://www.culturalfarming.com/Resources/civic_media/PostHuman.mov
 
--[[User:Mila|Mila]] 07:53, 21 May 2010 (UTC)
 
Craig Venter and his team have built the genome of a bacterium from scratch and incorporated it into a cell to make what they call the world's first synthetic life form
 
[http://www.guardian.co.uk/science/2010/may/20/craig-venter-synthetic-life-form article]@Guardian.co.uk. Watch the video.
 
--[[User:Bernd|Bernd]] 11:03, 21 May 2010 (UTC)
----
 
====Links to my project====
Hello everbody!
I'm Yu Xiaorui
I add a link to my Project.
You can Find it in the main page of Synthetic Biology Wiki
Or Click here:
* '''[[GMU:Synthetic_Biology/My Flower| My Flower]]'''<br>I put my review about the presentation I made today on.<br>
 
'''<span style="color:#FF69B4">Please go and leave comment or suggestion!
That's very important to me!</span>'''
<br>BTW, thank the comment left by Dominic,very helpful!<br>
 
--[[User:yuxiaorui|Yu Xiaorui]] 17:02, 20 May 2010 (UTC)
----
 
====Comment====
 
Now, the scientific standpoint concerning your ideas, Yu.
 
1st idea) Analyzing the heartbeat, blood pressure and temperature is a pretty good starting point. Those are, by the way, non-invasive standard techniques used in every hospital today (as you know). So the idea to measure those is not far fetched.
Those indicators can indeed tell you, if there is something really wrong with your cat. But they are insufficient for the diagnosis of a certain disease or even a certain mood. If the cat is excitet blood pressure, heartbeat and temperature will go up, probably. The same could happen if the cat gets sick.
 
So what came to my mind was whether you should think about adding some more "input" parameters. I listed some of those in the last comment I made below (hormones, gene expression detecteble from RNA in human blood).
 
I like the idea about a screen, that will show the result of the analyses and system that would then treat the cat with a kind of special drug. You should probably think about the way, this treatment could happen. Is there i.e. a machine inside the cat that would apply those drugs? Are there cells that would produce the drugs? If so, how would they get the message, that they sould produce a drug? (the latter two thinks are typical synthetic biology problems and thus very interesting, indeed).
 
2nd idea) I like this idea very much! Again, you should thinks about the parameters you want to use in order to detect the mood of a person. As I said, hormones could be a very good indicator. Bernd presented a very nice animation about facial pattern recognition to us in Heidelberg once. If you didn't see it before, you should probably have a look at it [http://www.vimeo.com/3381151 here] (I hope that is the right one...).
 
What I really love about this idea is the plant part. Plants making any kind of scent in order to smoothen your mood is really cool and would for sure need synthetic biology for engineering those plants. So the direction is really good in my opinion.
 
The interface between the human feelings and the plant is of course important in your project. Think about possible ways, that could be done. What I can tell you already is, that people are working hard in order to conntect cells (i.e. neurons, that means nerve cells) with computers. It has been shown in many studies that you can use elecrtricity in order to influence cells. Another good input is light, for example. Recent studies show, that light can be used in order switch on or off different (previously engineered) systems in a cell.
So what comes to my mind is: What about putting the plants under a certain light source. In case the person is agressive, red light is turned on and the plant will start to produce a sweet smell or something.
In case a person is tired, the light will turn green and the plant produces a smell that will make the person wake up and so on.
So light whould be used to switch between the ordors produced.
In the synthetic biology reader I send to sebastian (I don't know whether you got that one) therer is a nice article where light was used in order to controll the movement of a simple worm-like organism.
Just as a rough suggestion.
 
The light sourece could be controlled by a computer that estimates the mood of the person from the different parameters.
So controlling behaviour of organisms using light should be possible.
 
Good luck for your work! I really liked those ideas pretty much!!
 
 
--[[User:dniopek|Dominik Niopek]] 13:42, 19 May 2010 (UTC)
----
 
====General Information and some specific Information about future vision of Personalized Medicine====
 
Some general hopefully interesting info for some of you. The personalized medicine idea (bacteria in gut) and some other ideas pointet me to a documentation I once saw in the ZDF about a future vision of our life and society.
This documentary series called "2057- Unser Leben in der Zukunft" ran some time ago. Although one could controversely discuss the scientific content in those documentations, I find they are interesting and they might be inspiring. The first episode is about future healthcare and personalized medicine. Although some of the ideas sound strange at first hand, people are already working on many of those (i.e. the organ inject printer) [http://www.sciencedaily.com/releases/2007/02/070221093208.htm]
You can find the ZDF documentary series here: [http://www.youtube.com/results?search_query=2057+unser+leben+in+der+zukunft&aq=f Youtube: 2057- Unser Leben in der Zukunft]
 
 
b) The movie GATTACA might also be interesting [[wikipedia:Gattaca]]
 
Furthermore, I already told you about sequencing from simple blood samples.
Sequencing is the technology used to read the genetic code (AGCTTACCTTACC...). Therefor physical DNA (or RNA, I come to that later) is needed. DNA can simply be taken out from cells, i.e. cells of your skin or even blood plasm and serum. You can find some Information about DNA Sequencing on [[wikipedia:Sequencing]].
 
So why is that interesting?
 
1) Well, i.e. for diagnosis of genetic diseases. Recent studies showed, that DNA sequencing from the blood of pregnant women can be used to determine whether the fetus (baby) has the predisposition for a certain genetic disease. Keep in mind, that the DNA is sort of the genetic building plan of evey cell. So you can get information about this building plan and whether it has some errors here and there. Find some information about DNA Sequencing from blood [http://www.pnas.org/content/105/42/16266.full here].
 
2) Sequencing not the DNA, but the RNA is also very interesting, as the amount of RNA present in a cell gives you information about the gene expression (= the genes turned on and those turned off at a certain timepoint). RNA is the molecule that is used to translate the messages coded on the DNA in a from, that the inner cell machinary can read this massage and make the proteins. Proteins are the effector molecules and can be seen as the little machines, controlling the behaviour of a cell (i.e. energy production, movement, cell division- nearly everything). Strongly simplified, one can say, that one gene codes for a certain RNA and that RNA codes for a certain protein.
 
DNA --> RNA --> Protein
 
The more RNAs of the same type are present in a cell, the more proteins of the same type are made. So, if I do RNA sequencing, I get the information about the genes that are turned on or off, and I can even tell in which ratio that happenes. Biologists are talking about gene overexpression (= genes turned on at a higher level than normal) and underexpression (= genes turned on at a lower level than normal).
Unnormal gene expression is a typical indicator for a disregulation in a cell and can therefor be indicator for a disease. In many diseases the gene expression (and therefor the gene regulation) is unnormal. But not only diseases lead to different gene expression: When you eat and drink, when you jump into cold water and in other situations gene expression might be altered.
 
Coming back to the point: Sequencing RNA from human blood is possible since some years. In the future, as automated sequencing gets better and cheaper, that could give us the oppotunity to have a sort of online-look onto our gene expression. We would simply take blood samples and put them into a full-automatic (pocket?) sequencer.
 
Today, RNA analysis from blood samples is used i.e. for the [[wikipedia:HIV test| HIV-diagnosis]] and is also taken into account for [[wikipedia:HIV test|cancer diagnosis]]. In general, if the RNA sequencing from blood will get better and better, we will probably be able to look at our gene expression profile online!
 
 
Despite those technologies, another important marker in the blood, especially for the detection of the mood and feelings of the persons are [[wikipedia:Hormones|hormones]]. Hormones have been shown to have a strong influence on many body functions, including blood pressure and heartbeat. Furthermore they have a strong influence on the way we feel and act. Lovers have a certain hormone-cocktail in their blood, people being excited or agressive have a high adrenaline level in their blood. In animal studies it was shown, that by injecting a certain hormone into animals normally not living in groups, they would be nice and friendly living with the group of their kind afterwards (I will look up which animal that was and add that later).
 
I hope their has been at least some interesting information in this much too long paragraph :)
 
 
--[[User:dniopek|Dominik Niopek]] 13:16, 19 May 2010 (UTC)
----
 
====My ideas about this project====
I have some more ideas about this project.
Please make comment and let me know if they are good!
If you know some scientific Theories which can support my idea,Please tell me!
I really appreciate for that! 
 
First one I call it Cat reader.
It has two parts.
Part I you can put it in your car's body.
It will analyze the datas of your cat,heart beat, blood pressure锛?temperature ect.
By these, it can tell the mood of your cat and its health situation.
 
The result will be showed in part II, which is a pet collar with a screen.
Through this the owner can see how is the cat doing.
Hungry, thirsty, sick,angry or happy.Then he can take care of it better.
 
Another function of the part I is it can give some medicine to the cat.
For example, if the cat hurt itself or it is ill, and part I detects that.
Besides show on the screen,it will also give some medicine as first add.
 
 
Another idea is a indoor system,which is similar to the first one.
But it is make up with a flower and an analyze machine.
The analyze machine is like the Part I in Cat reader, But it is installed in human body.
It can tell your mood,then send signal to a receiver which is connected to the plant.
Then the flower will give off different scent to sooth your mood.
Also you can set the flower manually according to your need.
For example you'd like to keep awake or sleep well.
 
 
--[[User:yuxiaorui|Yu Xiaorui]] 16:45, 18 May 2010 (UTC)
----
 
====DIYbio and Personalized Medicine====
 
Andrew Hessel, one of the cofounders of the company [http://pinkarmy.org/ Pink Army Cooperative], an open source project for the development of new, personalized breast cancer treatments . There is a nice video on youtube, where Andrew Hessel talks about the future of synthetic biology and also about the Pink Army: [http://www.youtube.com/watch?v=niQ0kkgPxJk Andrew Hessel on Youtube].
 
 
 
--[[User:dniopek|Dominik Niopek]] 13:07, 16 May 2010 (UTC)
----
 
====Bacteria for personalized Medicine and other interesting iGEM ideas====
 
Some iGEM-Teams from 2008 and 2009 worked on using bacteria for personalized medicine. The idea to put them into the human gut and let them react to either internal or external stimuli has led to some interesting wet-lab projects.
 
Probably most famous in the iGEM-context is the work from Taipei 2008 (have also a look on wiki design an figures): [http://2008.igem.org/Team:NYMU-Taipei Taipei Wiki 2008]
 
Caltech 2008 took a similar approach: [http://2008.igem.org/Team:Caltech Caltech Wiki 2008]
 
Also interesting: the bacto-joghurt idea by MIT 2008: [http://2008.igem.org/Team:MIT MIT Wiki 2008]
 
You sould also have a brief look on those projects here, especially on the kind of idea they focus on. All of them are really special in their way:
 
Edinburgh 2009 on the detection of land mines: [http://2009.igem.org/Team:Edinburgh Edinburgh Wiki 2009]
 
Calgary 2009 and their human practices project on a Second Life Synhetic Biology world: [http://2009.igem.org/Team:Calgary# Calgary Wiki 2009]
 
Tokyo Tech 2009 on terraforming Mars (very cool idea): [http://2009.igem.org/Team:Tokyo_Tech Tokyo Tech Wiki 2009]
 
Virginia 2009 on water cleaning: [http://2009.igem.org/Team:Virginia Virgina Wiki 2009]
 
Tokyo Tech 2008 on an E. coli based touch display: [http://2008.igem.org/Team:Tokyo_Tech Tokyo Tech Wiki 2008]
 
Furthermore, you should have a look at some team presentations. Besides the finalists presentations from 2008 and 2009 that are interesting anyways, the following ones have been really cool and fun:
Tokyo Tech 2009, Calgary 2009
 
 
Have fun! I'm looking forward to see you soon in Heidelberg! More information is about to come in this blog, soon.
 
--[[User:dniopek|Dominik Niopek]] 12:49, 16 May 2010 (UTC)
----
 
====“Synthetic Biology” Sparks Nano-Terror Scenario====
[http://newhavenindependent.org/index.php/archives/entry/synthetic_biology_sparks_nano-terror_scenario/ Article] about misuses, expected and unexpected consequences  of Syn Bio.
Includes some links to other resources about safety issues.
 
 
 
 
--[[User:Bernd|Bernd]] 12:31, 14 May 2010 (UTC)
----
====Scienceblogs on Synbio====
Interesting read about Synbio.  There is an [http://scienceblogs.com/oscillator/2010/05/synthetic_biology_art.php article] featuring [http://www.tuurvanbalen.com/ Tuur van Balen's] work
 
 
 
--[[User:Bernd|Bernd]] 14:50, 12 May 2010 (UTC)
----
====New Scientist CultureLab====
[http://www.newscientist.com/blogs/culturelab/2010/05/art-science-poll.php Art meets science: What do you think of it all?]
 
 
''Over the next few days we'll be publishing a series of articles looking at art-science collaborations, and to kick things off we've set up a quick survey.'' (New Scientist)
 
[http://www.newscientist.com/blogs/culturelab/2010/05/art-meets-science-when-worlds-collaborate.php Overview]
 
[http://www.newscientist.com/blogs/culturelab/2010/05/art-meets-science-curator.php Art meets science: A curator who wants to open windows]
 
[http://www.newscientist.com/blogs/culturelab/2010/05/art-meets-science-aesthetics-politics-and-metaphysics.php Art meets science: Aesthetics, politics and metaphysics]
 
[http://www.newscientist.com/blogs/culturelab/2010/05/art-meets-science-physicist.php Art meets science: Physicist in a cultural landscape]
 
[http://www.newscientist.com/blogs/culturelab/2010/05/art-meets-science-lingua-digica.php Art meets science: Speaking a lingua digica]
 
[http://www.newscientist.com/blogs/culturelab/2010/05/art-meets-science-state-of-the-art.php Art meets science: Catch up with the state of the art]
 
 
--[[User:Bernd|Bernd]] 12:55, 12 May 2010 (UTC)
----
====Cultural Probes====
If you are interested in Design as a research tool, you should
read this.
[http://cleo.ics.uci.edu/teaching/Winter10/231/readings/3-GaverDunnePacenti-CulturalProbes.pdf Cultural Probes]
 
 
--[[User:Bernd|Bernd]] 16:29, 11 May 2010 (UTC)
----
====Neighborhood Science====
The Medialab Prado in Madrid is calling for collaborators for their Interactivos?'10, the topic is 'Neighborhood Science'.
http://medialab-prado.es/article/interactivos10_ciencia_de_barrio_convocatoria_de_colaboradores
 
 
--[[User:Sebastian|sebastian]] 13:45, 11 May 2010 (UTC)
----
====NextNature.net====
Please have a look at http://www.nextnature.net/.  There are a couple
Synbio related articles like [http://www.nextnature.net/2010/05/fludoc-glowing-bacteria-tell-if-you-have-flue/ FluDOC – Glowing Bacteria show if you have Influenza]




--[[User:Bernd|Bernd]] 12:42, 9 May 2010 (UTC)
----
====FYI: Literaturliste Grafik und Gestaltung====
[[GMU:Die neue U-Bahn#Literatur|Literaturliste Grafik und Gestaltung]]


--[[User:Sebastian|sebastian]] 13:11, 6 May 2010 (UTC)
--[[User:Sebastian|sebastian]] 13:11, 6 May 2010 (UTC)
----
----
====Michiko Nitta: Extreme Green Guerrillias====
====Michiko Nitta: Extreme Green Guerrillias====
I think we have mentioned the project already, but give it a look.
I think we have mentioned the project already, but give it a look.
Line 153: Line 741:
----
----
====Research/Link: Biopunk Manifesto====
====Research/Link: Biopunk Manifesto====
The Biopunk Manifesto by Annalee Newitz [http://www.ekac.org/biopunk.html]
[http://www.ekac.org/biopunk.html The Biopunk Manifesto by Annalee Newitz]






----
----
====Kac goes Hopfengärtner====
====Kac goes Hopfengärtner====
Apparently bioart allstar E.Kac features in his recent work methods employed by B.Hopfengärtner a couple of years ago ;)
Apparently bioart allstar E.Kac features in his recent work methods employed by B.Hopfengärtner a couple of years ago ;)

Latest revision as of 12:11, 23 October 2011

Biologie für Fortgeschrittene

Legostein 13 Legoanimation.

--sebastian 11:59, 22 September 2010 (CEST)


cells.de - Der Onlinedienst zur Zellbiologie mit Videos und interaktiven Medien

http://www.cells.de/cellsger/index.jsp
--sebastian 21:31, 2 September 2010 (CEST)



Interesting Reading: Das Buch des Lebens

"Das Buch des Lebens: wer schrieb den genetischen Code?" von Lily E. Kay. ISBN 3-518-29346-X

Recommended by Felix Sattler
--sebastian 19:44, 2 September 2010 (CEST)


Bio:Fiction Filmfestival about Synthetic Biology - !!DEADLINE EXTENDED!!

The new deadline will be December 1st 2010! Hurry up!

--sebastian 15:28, 22 July 2010 (UTC)


iGEM: Preliminary Project Descriptions Due

As the iGEM calender of events shows the preliminary project description is due on 16. of july. Please do not forget to take care of that.

--sebastian 17:54, 7 July 2010 (UTC)


"Wir wissen nichts"

Spiegel Interview with Craig Venter

--sebastian 10:43, 5 July 2010 (UTC)


Marke.6 layout

I have uploaded the newest version layout of Marke.6 application in dropbox.
But Mila said she didn't see it. So I upload it to wiki now. here is it!

--Sharklu 21:37, 4 July 2010 (UTC) Lu Jiayuan


Artifacts from the future (Wired)

In each issue of Wired magazine, at the end of the book, there’s a page called “artifact from the future” that consists in a heavily photoshopped photo of an object supposedly common in the future. These visual elements depicts designers, researchers, pundits’ prognostications about how the world “will look like in 10, 20 or 100 years“. Yes, it’s “will” not “may”, as shown in this article. See some examples systematically listed by sceptycal futurist Stuart Candy


--Bernd 19:45, 2 July 2010 (UTC)


Knockout Moss

There is also some more information about the moss on Prof. Dr. Ralf Reski's homepage of University Freiburg:

http://www.plant-biotech.net/

Yeah and the best about this moss is....you can order it!!!

At the university of freiburg international moss stock center:

http://www.moss-stock-center.org/

And that only for 50€ per mutant knock-out plant and only 5€ for the ecotype physcomitrella patens moss! ah yeah plus shipping!

--Wawa 13:52, 30 June 2010 (UTC)

In co-operation with the chemical company BASF Ralf Reski and coworkers established a collection of knockout mosses that is used for gene identification last passage here:

wikipedia:de:Knockout Moss


--Bernd 19:45, 2 July 2010 (UTC)


Epigenetics

Ghost in your genes



DIY Bio: Open Gel Box 2.0

A DIY Gel electrophoresis box from Pearl Biotech

see also here.


--sebastian 15:16, 23 June 2010 (UTC)


Cellularity

<videoflash type=vimeo>10274649|600|340</videoflash>

The central idea behind this scenario is that we might one day understand life, not as a hard-edged category, but as a graduated scale between nonliving and living things. Each developmental stage in chemical cell biology is slightly more alive than the stage before. To formalize this idea, I designed a speculative definition of life named the “Cellularity Scale” which shows how five different living properties accumulate at each subsequent stage. Of course, this is a purely speculative definition of life, consistent with the scenario I have designed. If the Chell project or any of the several other bottom-up attempts at abiogenesis are successful, they will quite possibly offer an entirely different picture.

James King James' article on Seedmagazine.com


--Bernd 15:35, 22 June 2010 (UTC)


AI Game

Just found on the c't magazine: antme,a software simulating ants which behave according to an artificial intelligence. The AI needs to be coded beforehand. The project is aimed to C# beginners to teach programming. I see some parallels to our bacteria-game: we "code" DNA, it takes place in a closed environment etc.



Game and iGEM Project 2008

Just a first, (finally not so) brief comment on the idea of making a kind of computer game, but with genetically modified bacteria. As some of you might already know, the iGEM project of our team in 2008 was about creating an artificial preditor-prey system by genetically modifying bacteria. We wanted therefore to create bacteria that would:

a) swim towards a target bacteria
b) kill that target bacteria when it would reach it

The second part (killing) worked really good, but the first part (swimming towards a certain target) didn't work out so good. But anyway, there are interesting implications in both parts I want to comment on.

a) making bacteria swim in a certain direction
It is pretty well known in literature, that bacteria have certain so-called chemotaxis receptors [1] on their surface. These receptors are, in nature, used for recognizing attractand molecules (nutrition, i.e. sugar) or repellents (i.e. toxic molecules). It is possible to influence (I would not say control, but at least strongly influence) the direction in that bacterial colonies on an agar plate swim by putting repellent and attractand molecules at different points on the plate. To give you one example: If I would put aspartate in the middle of an agar plate with E. coli colonies on it, the E. coli would move in direction of the aspartate. Their are different E. coli strains, that do contain different chemotaxis receptors or even no receptors. Furthermore, there are bacteria that swim fast, slow or bacteria that can't even swim at all. Find a comparisn of swimming and not-swimming bacteria here. In general that could be interesting if you wanted to make bacteria swim toward each other. To give you an impression on what swimming bacteria on a plate would look like, here some examples from my bachelor thesis media:Bacheloararbeit_Dominik_Niopek_druck.pdf. In the 'center' assays, I just put bacteria on either site of the plate. As you can see, the swim rings of the two bacterial colonies meet in the middle after 24 hours (even faster, ie. 6 or 12 hours, depends on the bacteria). In the 'centerline' assay I spottet immobilized bacteria in one line in the middle, and mobile bacteria again on either site of the line.

Those so called swarm assays or swarm agar plates are really simple to prepare, easy to use. If you used different bacteria expressing color pigments (red, green, black), I am sure you could see how one bacteria would take over the space of the others, mix up with them, kill them etc.

b) making bacteria kill other bacteria
In 2008 we also developed a killing mechanism which worked pretty good. The principle is the following: One bacterial strain was engineered to secrete a certain messenger molecule, called Autoinducer-1. The other bacterial strain was engineered to recognize Autoinducer-1 and thereby activate the production of a bacterial toxin called colicin [2]. This means: If both bacterial strains are nearby each other, the one would start to kill the other. It is no problem to label one bacterial strain in red and the other in green and to visualize how the green bacteria die if they are nearby the red ones under a microscope (figure 17 again on this page). The same should also be possible on swarm agar plates.
With swimming bacteria on swarm agar plates, you have many options to play around, as their are so many different bacterial strains (swimming slower, faster, not at all, recognizing substances etc.). Take this just as some general comments to think about. In case their is something in that comments, that interests you in particular, please don't hesitate to shoot me an e-mail (d.niopek@gmx.de) or call me (01577-4054784). As I did my bachelor thesis on this topic (swimming bacteria), I would be very happy to provide you with all necessary information and help.


--Dniopek 23:18, 9 June 2010 (UTC)


Go with the flow

Flow-game-screenshot-4.jpg

I found a very interessting game over the internet. It's a MFA thesis project from 'thatgamecompany' and called 'flow'.

The game is about a small organism flowing through a watery atmosphere while consuming other small organisms. Through consuming you as a player can evolve the abilities and appearance of your organism.

'Thatgamecompany' is a small colloboration of game designers which working only with experimental games like 'flow'.

Everything is mostly about gaining new experiences and inspiring their players via special sound and atmosphere....and without words!


--Wawa 22:14, 9 June 2010 (UTC)


Horror Movie about a Human-Animal Synbio Hybrid

There is a movie playing in cinemas in germany at the moment about a synthetically created human-animal monster.

It is rather silly and acutally the name "Splice" is scientifically completely incorrect, but if you like to check it out, I'm sure it's worth a laugh (now that you know more about genetics than the average person)

Here's a wikipedia link [[wikipedia:Splice (film)]

Enjoy!


--Laura iGem 17:51, 9 June 2010 (UTC)

BioArts in Austrian Magazine

An Austrian magazine for genome research, "Genosphären", is running an issue on BioArts and Synthetic Biology this month [3]. Since you probably won't get your hands on it, here is a round-up of artists that I could not find on your link-list yet. I am sorry if this is somehow redundant in case I missed blog entries, I tried to search through all of them.

- Jun Takita [4] created a model of his brain and planted transgenic moss on it. This moss can glow in the dark due to the Luciferase-Gene. This resembles the complex signals that occur in the brain.

- Gary Schneider, who takes genetic portraits of people (which is admittedly not the most original thing to do) [5]

- Adam Brandejs, who presented his sci-fi product, "Genpets", on a website disguised as a normal webshop and raised some outrage with his anti-allergic perfect pet. [6]

- Karsten Panzer, who created a colour-coding for the visiual sensation of genetic information [7]

I hope this gives some inspiration!


--Laura iGem 17:35, 6 June 2010 (UTC)


Zeit Artikel

Synthetische Biologie -Leben 2.0
Was passiert, wenn es der Bio-Industrie gelingt, den menschlichen Körper neu zu programmieren


--max 18:00, 5 June 2010 (UTC)


The Procreative Dinner

An ephemeral work between art, science and gastronomy. Happening by Prune. Nice way of bringing people in touch with the topic...and another example of a collabortation of art and science.


--Mila 14:20, 3 June 2010 (UTC)


Six part Series "Synthetische Biologie" on D-Radio

Schwerpunkt Synthetische Biologie


--Bernd 09:19, 3 June 2010 (UTC)


More Photos

I have uploaded some photos which I took during the retreat.
Enjoy it.!


--Sharklu 00:36, 2 June 2010 (UTC)Lu Jiayuan


Back from the retreat

The firs images of our lab experiences in Hedeilberg and our fruitful retreat to Asselheim can be found here. Please feel free to add more pictures!


--sebastian 16:57, 1 June 2010 (UTC)


Richard Jones' comment on Craig Venters successful insertion of a synthetic genome into a bacteria

"One might almost suspect that there is a symbiosis going on here, between those scientists anxious to maximise the significance of their work, and bioethicists in search of an issue to raise their own profile. After all, if a piece of science is worth worrying about, it must be important. It’s not that I don’t think that these developments have potentially important societal and ethical implications – but it seems to me that these would be better considered from a standpoint that was a little more critical." Richard Jones on his Blog.


--sebastian 16:10, 26 May 2010 (UTC)

First human 'infected with computer virus'

Article on BBC News


--sebastian 15:43, 26 May 2010 (UTC)


A New Plant

Hello! Everyone!

I have built my project page...
a new plant
Welcome to do something!
--


Sharklu 16:51, 24 May 2010 (UTC)


To live, to err, to fall, to triumph, to recreate life out of life – the most pretentious bacterium ever

I'd create an animal that excretes meat, just to give vegetarians pause for thought. Ethically, what's the problem with eating a sausage, if it's been harmlessly pooed out by an animal? To sweeten the pill yet further, what if you put pleasure receptors in the animal's colon, so it actively enjoys the sausage-creation process – enjoys it to such a degree that it chases you down the street, yelping in orgasmic delight and producing a string of pan-ready chipolatas? If you think that's disgusting, I'd just like to point out that it's far less revolting than killing a pig with a bolt gun then mashing it up into sausagemeat. Charlie Brooker: So, artificial life is here, courtesy of Craig Venter. Time to remix humankind…


--Bernd 11:43, 24 May 2010 (UTC)


Some more links on synthetic life

Newscienist: Immaculate creation: birth of the first synthetic cell

NYTimes: Researchers Say They Created a ‘Synthetic Cell’


--Bernd 09:17, 24 May 2010 (UTC)


Kokoromo : My project is online

So I also put up my project... ko_ko_ro_mo

Please don't be shy and have a look.

I really look forward to discuss it with you all.

--Wawa 23:18, 22 May 2010 (UTC)


Response to 'My Flower'

First response is written ^^

Have fun!

--Wawa 15:51, 22 May 2010 (UTC)

Update on my page

Hello everybody.
There is new content on my project page.
It's about my ideas of improving my project.
The link is below:

Please visit and leave comment!
Thanks!

--Yu Xiaorui 12:02, 22 May 2010 (UTC)


Pass the impossimpleble :)

Oh my! Are they already this far in development?

I found a pretty amazing TV documentation-series, (if you can call like that...because its more a idealistic utopia), of the berlin TVchannel Phoenix. It is about the possibilities which may occur while living in future with new technologies. It think it would be very interessting for some of you.

To my shame it is only in german at the moment, but under the link you can find some informations to the technolgies and the scientists.


[8] Here comes part 1 of 3

First Episode - Living in the future - Humans

  • houses and also clothes will be connected to the internet to control our health und living status every single moment electronic fibre by Dr. Prof. Sundaresan Jayaraman (Georgie Institute of Technology)
  • cars will fly in the air with a satelite electronical guide system to provied us from traffic jams and accidents flying car by Dr. Paul Moller (Moller International)
  • stemcells can be used to create new organs tissue engineering by Dr. Stefan Jockenhövel (Helmholz-Institute for biomedical technique)
  • 3D genomic printer to create organs layer by layer by Dr. Prof. Thomas Boland (Clemson University)
  • food wont make us fat anymore because of genetic engineered proteins by Dr. Prof. Med. Rob Hammer (Wageningen Centre of Food Science)
  • cure paraplegia or other neural-muscular deseases with electronic sensor body-implants you can control with your thoughts sensors by Prof. Dr. John Donoghue (Brown University)
  • computer surgery sytems controlled by doctors for precise working and without viral infections by Dr. Oliver Burgert (innovation-centre for computer-assisted surgery)


But all that glitters is not gold? Or?

Here also a small outlook what may happend with our health system in future. Also german *yeah I know I know thats stupid*.

[9] It is called: 'Leichen im Keller' or like the englisch proverb 'scelletons in the (closet) cellar'

I think it is rather nice^^

I look foward to have some smalltalk about the chances and risks of synbio with you all.

--Wawa 18:29, 21 May 2010 (UTC)


Its done

How does it feel to have created artificial life, Dr Venter?

http://www.independent.co.uk/news/people/profiles/dr-craig-venter-so-doctor-how-does-it-feel-to-have-created-artificial-life-1978873.html

http://www.culturalfarming.com/Resources/civic_media/PostHuman.mov

--Mila 07:53, 21 May 2010 (UTC)

Craig Venter and his team have built the genome of a bacterium from scratch and incorporated it into a cell to make what they call the world's first synthetic life form

article@Guardian.co.uk. Watch the video.

--Bernd 11:03, 21 May 2010 (UTC)


Links to my project

Hello everbody! I'm Yu Xiaorui I add a link to my Project. You can Find it in the main page of Synthetic Biology Wiki Or Click here:

  • My Flower
    I put my review about the presentation I made today on.

Please go and leave comment or suggestion! That's very important to me!
BTW, thank the comment left by Dominic,very helpful!

--Yu Xiaorui 17:02, 20 May 2010 (UTC)


Comment

Now, the scientific standpoint concerning your ideas, Yu.

1st idea) Analyzing the heartbeat, blood pressure and temperature is a pretty good starting point. Those are, by the way, non-invasive standard techniques used in every hospital today (as you know). So the idea to measure those is not far fetched. Those indicators can indeed tell you, if there is something really wrong with your cat. But they are insufficient for the diagnosis of a certain disease or even a certain mood. If the cat is excitet blood pressure, heartbeat and temperature will go up, probably. The same could happen if the cat gets sick.

So what came to my mind was whether you should think about adding some more "input" parameters. I listed some of those in the last comment I made below (hormones, gene expression detecteble from RNA in human blood).

I like the idea about a screen, that will show the result of the analyses and system that would then treat the cat with a kind of special drug. You should probably think about the way, this treatment could happen. Is there i.e. a machine inside the cat that would apply those drugs? Are there cells that would produce the drugs? If so, how would they get the message, that they sould produce a drug? (the latter two thinks are typical synthetic biology problems and thus very interesting, indeed).

2nd idea) I like this idea very much! Again, you should thinks about the parameters you want to use in order to detect the mood of a person. As I said, hormones could be a very good indicator. Bernd presented a very nice animation about facial pattern recognition to us in Heidelberg once. If you didn't see it before, you should probably have a look at it here (I hope that is the right one...).

What I really love about this idea is the plant part. Plants making any kind of scent in order to smoothen your mood is really cool and would for sure need synthetic biology for engineering those plants. So the direction is really good in my opinion.

The interface between the human feelings and the plant is of course important in your project. Think about possible ways, that could be done. What I can tell you already is, that people are working hard in order to conntect cells (i.e. neurons, that means nerve cells) with computers. It has been shown in many studies that you can use elecrtricity in order to influence cells. Another good input is light, for example. Recent studies show, that light can be used in order switch on or off different (previously engineered) systems in a cell. So what comes to my mind is: What about putting the plants under a certain light source. In case the person is agressive, red light is turned on and the plant will start to produce a sweet smell or something. In case a person is tired, the light will turn green and the plant produces a smell that will make the person wake up and so on. So light whould be used to switch between the ordors produced. In the synthetic biology reader I send to sebastian (I don't know whether you got that one) therer is a nice article where light was used in order to controll the movement of a simple worm-like organism. Just as a rough suggestion.

The light sourece could be controlled by a computer that estimates the mood of the person from the different parameters. So controlling behaviour of organisms using light should be possible.

Good luck for your work! I really liked those ideas pretty much!!


--Dominik Niopek 13:42, 19 May 2010 (UTC)


General Information and some specific Information about future vision of Personalized Medicine

Some general hopefully interesting info for some of you. The personalized medicine idea (bacteria in gut) and some other ideas pointet me to a documentation I once saw in the ZDF about a future vision of our life and society. This documentary series called "2057- Unser Leben in der Zukunft" ran some time ago. Although one could controversely discuss the scientific content in those documentations, I find they are interesting and they might be inspiring. The first episode is about future healthcare and personalized medicine. Although some of the ideas sound strange at first hand, people are already working on many of those (i.e. the organ inject printer) [10] You can find the ZDF documentary series here: Youtube: 2057- Unser Leben in der Zukunft


b) The movie GATTACA might also be interesting wikipedia:Gattaca

Furthermore, I already told you about sequencing from simple blood samples. Sequencing is the technology used to read the genetic code (AGCTTACCTTACC...). Therefor physical DNA (or RNA, I come to that later) is needed. DNA can simply be taken out from cells, i.e. cells of your skin or even blood plasm and serum. You can find some Information about DNA Sequencing on wikipedia:Sequencing.

So why is that interesting?

1) Well, i.e. for diagnosis of genetic diseases. Recent studies showed, that DNA sequencing from the blood of pregnant women can be used to determine whether the fetus (baby) has the predisposition for a certain genetic disease. Keep in mind, that the DNA is sort of the genetic building plan of evey cell. So you can get information about this building plan and whether it has some errors here and there. Find some information about DNA Sequencing from blood here.

2) Sequencing not the DNA, but the RNA is also very interesting, as the amount of RNA present in a cell gives you information about the gene expression (= the genes turned on and those turned off at a certain timepoint). RNA is the molecule that is used to translate the messages coded on the DNA in a from, that the inner cell machinary can read this massage and make the proteins. Proteins are the effector molecules and can be seen as the little machines, controlling the behaviour of a cell (i.e. energy production, movement, cell division- nearly everything). Strongly simplified, one can say, that one gene codes for a certain RNA and that RNA codes for a certain protein.

DNA --> RNA --> Protein

The more RNAs of the same type are present in a cell, the more proteins of the same type are made. So, if I do RNA sequencing, I get the information about the genes that are turned on or off, and I can even tell in which ratio that happenes. Biologists are talking about gene overexpression (= genes turned on at a higher level than normal) and underexpression (= genes turned on at a lower level than normal). Unnormal gene expression is a typical indicator for a disregulation in a cell and can therefor be indicator for a disease. In many diseases the gene expression (and therefor the gene regulation) is unnormal. But not only diseases lead to different gene expression: When you eat and drink, when you jump into cold water and in other situations gene expression might be altered.

Coming back to the point: Sequencing RNA from human blood is possible since some years. In the future, as automated sequencing gets better and cheaper, that could give us the oppotunity to have a sort of online-look onto our gene expression. We would simply take blood samples and put them into a full-automatic (pocket?) sequencer.

Today, RNA analysis from blood samples is used i.e. for the HIV-diagnosis and is also taken into account for cancer diagnosis. In general, if the RNA sequencing from blood will get better and better, we will probably be able to look at our gene expression profile online!


Despite those technologies, another important marker in the blood, especially for the detection of the mood and feelings of the persons are hormones. Hormones have been shown to have a strong influence on many body functions, including blood pressure and heartbeat. Furthermore they have a strong influence on the way we feel and act. Lovers have a certain hormone-cocktail in their blood, people being excited or agressive have a high adrenaline level in their blood. In animal studies it was shown, that by injecting a certain hormone into animals normally not living in groups, they would be nice and friendly living with the group of their kind afterwards (I will look up which animal that was and add that later).

I hope their has been at least some interesting information in this much too long paragraph :)


--Dominik Niopek 13:16, 19 May 2010 (UTC)


My ideas about this project

I have some more ideas about this project. Please make comment and let me know if they are good! If you know some scientific Theories which can support my idea,Please tell me! I really appreciate for that!

First one I call it Cat reader. It has two parts. Part I you can put it in your car's body. It will analyze the datas of your cat,heart beat, blood pressure锛?temperature ect. By these, it can tell the mood of your cat and its health situation.

The result will be showed in part II, which is a pet collar with a screen. Through this the owner can see how is the cat doing. Hungry, thirsty, sick,angry or happy.Then he can take care of it better.

Another function of the part I is it can give some medicine to the cat. For example, if the cat hurt itself or it is ill, and part I detects that. Besides show on the screen,it will also give some medicine as first add.


Another idea is a indoor system,which is similar to the first one. But it is make up with a flower and an analyze machine. The analyze machine is like the Part I in Cat reader, But it is installed in human body. It can tell your mood,then send signal to a receiver which is connected to the plant. Then the flower will give off different scent to sooth your mood. Also you can set the flower manually according to your need. For example you'd like to keep awake or sleep well.


--Yu Xiaorui 16:45, 18 May 2010 (UTC)


DIYbio and Personalized Medicine

Andrew Hessel, one of the cofounders of the company Pink Army Cooperative, an open source project for the development of new, personalized breast cancer treatments . There is a nice video on youtube, where Andrew Hessel talks about the future of synthetic biology and also about the Pink Army: Andrew Hessel on Youtube.


--Dominik Niopek 13:07, 16 May 2010 (UTC)


Bacteria for personalized Medicine and other interesting iGEM ideas

Some iGEM-Teams from 2008 and 2009 worked on using bacteria for personalized medicine. The idea to put them into the human gut and let them react to either internal or external stimuli has led to some interesting wet-lab projects.

Probably most famous in the iGEM-context is the work from Taipei 2008 (have also a look on wiki design an figures): Taipei Wiki 2008

Caltech 2008 took a similar approach: Caltech Wiki 2008

Also interesting: the bacto-joghurt idea by MIT 2008: MIT Wiki 2008

You sould also have a brief look on those projects here, especially on the kind of idea they focus on. All of them are really special in their way:

Edinburgh 2009 on the detection of land mines: Edinburgh Wiki 2009

Calgary 2009 and their human practices project on a Second Life Synhetic Biology world: Calgary Wiki 2009

Tokyo Tech 2009 on terraforming Mars (very cool idea): Tokyo Tech Wiki 2009

Virginia 2009 on water cleaning: Virgina Wiki 2009

Tokyo Tech 2008 on an E. coli based touch display: Tokyo Tech Wiki 2008

Furthermore, you should have a look at some team presentations. Besides the finalists presentations from 2008 and 2009 that are interesting anyways, the following ones have been really cool and fun: Tokyo Tech 2009, Calgary 2009


Have fun! I'm looking forward to see you soon in Heidelberg! More information is about to come in this blog, soon.

--Dominik Niopek 12:49, 16 May 2010 (UTC)


“Synthetic Biology” Sparks Nano-Terror Scenario

Article about misuses, expected and unexpected consequences of Syn Bio. Includes some links to other resources about safety issues.



--Bernd 12:31, 14 May 2010 (UTC)


Scienceblogs on Synbio

Interesting read about Synbio. There is an article featuring Tuur van Balen's work


--Bernd 14:50, 12 May 2010 (UTC)


New Scientist CultureLab

Art meets science: What do you think of it all?


Over the next few days we'll be publishing a series of articles looking at art-science collaborations, and to kick things off we've set up a quick survey. (New Scientist)

Overview

Art meets science: A curator who wants to open windows

Art meets science: Aesthetics, politics and metaphysics

Art meets science: Physicist in a cultural landscape

Art meets science: Speaking a lingua digica

Art meets science: Catch up with the state of the art


--Bernd 12:55, 12 May 2010 (UTC)


Cultural Probes

If you are interested in Design as a research tool, you should read this. Cultural Probes


--Bernd 16:29, 11 May 2010 (UTC)


Neighborhood Science

The Medialab Prado in Madrid is calling for collaborators for their Interactivos?'10, the topic is 'Neighborhood Science'. http://medialab-prado.es/article/interactivos10_ciencia_de_barrio_convocatoria_de_colaboradores


--sebastian 13:45, 11 May 2010 (UTC)


NextNature.net

Please have a look at http://www.nextnature.net/. There are a couple Synbio related articles like FluDOC – Glowing Bacteria show if you have Influenza


--Bernd 12:42, 9 May 2010 (UTC)


FYI: Literaturliste Grafik und Gestaltung

Literaturliste Grafik und Gestaltung

--sebastian 13:11, 6 May 2010 (UTC)


Michiko Nitta: Extreme Green Guerrillias

I think we have mentioned the project already, but give it a look. It is illustrating the implications of extreme sustainable lifestyle, utilising genetic modifications and more.

http://www.myportfolio.me.uk/EGGs.htm


--sebastian 10:52, 6 May 2010 (UTC)


Bio-Fiction Film Festival

There is a synbio film festival in Vienna. The deadline ( 15. July) is perfect because it's one week after our final presentation. Should be interesting for some of you.

Have a look.

bio-fiction.com



--Bernd 12:01, 5 May 2010 (UTC)


PERFECT BODY (living sex machine)

I am really sorry that I couldnt be there on thursday for the presentation! So now my work in progress in a short movie - with:

.introduction

.perfect body kit

.magazine

.crossword

.drugstore-tv-spot

<videoflash type="vimeo">11366691|400|300</videoflash>


--Mila 22:25, 30 April 2010 (UTC)


Design will save the world

Inhabitat.com is an online plattform for ecological und biological projects in architecture, design, technology and art. Inventions from all over the world are presented here!

It is not directly something about synthetic biology, but you can still find a lot of nice and inspiring stuff for your work.

http://inhabitat.com


--Wawa 15:43, 28 April 2010 (UTC)


(re)Performing the Posthuman

http://reperformingtheposthuman.yolasite.com/

21/22 may 2010 The programme will include keynotes by Rosemary Klich, Jennifer Parker- Starbuck and Stelarc, paper presentations, performances, video showings, a small exhibition space and a gallery in Second Life.

About: "...models of subjectivity that call into question the humanist concept of the body as a biological entity, and as the "container" of the human subject"... "drawing attention to inconsistencies between the theory's wider cultural implications and socio-political realities, others insisting on the possibility of a biological definition of humanness"... "It is therefore now an apposite moment to revisit the idea of the posthuman, and posthumanist approaches to performance art and theatre. The aim of (re)Performing the Posthuman is to create an opportunity to do precisely this and to discuss in what form (if any) non-humanist concepts of the body and subjectivity may still be useful as a conceptual and analytical framework in performance arts."


--Mila 13:21, 25 April 2010 (UTC)


23andme special offer

© 23andMe, Inc. 2009. All rights reserved; distributed pursuant to a Limited License from 23andMe


Get your genetic health and ancestry checked with 23anme. Now for only 99$. Or maybe not.


--Bernd 20:23, 23 April 2010 (UTC)

Mmh, not anymore. Price is back to 499$.


--sebastian 08:27, 24 April 2010 (UTC)


Synbio on the go

reportage Synbio (english)

Introduction Synbio (German)

Dsicussion Synbio (German)


--JanD 15:37, 21 April 2010 (UTC)


Craig Venter on DNA and the sea

<videoflash type=youtube>E5X6Qy772YU|437|236</videoflash>


Craig Venter takes a break from his epic round-the-world expedition to talk about
the millions of genes his team has discovered so far in its quest to map the ocean’s
biodiversity.

Craig venter surveys the genetic biodiversity. In history surveying often meant taking possession.


--Bernd 17:35, 20 April 2010 (UTC)


Sk-Interfaces_Ausstellung

http://www.casino-luxembourg.lu/html_en/expositions/expoencours_skinterfaces.htm

Die Ausstellung ist leider schon vorbei, dabei waren aber die Größen der Branche: Art Orienté objet, Maurice Benayoun, Zane Berzina, Critical Art Ensemble, Wim Delvoye, Olivier Goulet, Eduardo Kac, Antal Lakner, Yann Marussich, Kira O’Reilly, Zbigniew Oksiuta, ORLAN, Philippe Rahm, Julia Reodica, Stelarc, Jun Takita, The Office of Experiments, The Tissue Culture and Art Project, Sissel Tolaas, Paul Vanouse.

Es gibt ein Minivideo auf der Seite.. --Mila 22:16, 18 April 2010 (UTC)


es gibt auch ein schönes, interaktives (was den umschlag betrifft) buch dazu!

vielleicht was für die bibliothek? (ist in der Unibibliothek vorhanden --max 20:27, 19 April 2010 (UTC))


--Ck schroeder 19:04, 19 April 2010 (UTC)


Heterogeneous Home

http://www.benhooker.com/heterogeneoushome/
get inspired
by sebastian 20:22, 14 April 2010 (UTC)



Try this at home: Extracting Human DNA

Instructional video

by sebastian 18:12, 13 April 2010 (UTC)


Research/Link: Biopunk Manifesto

The Biopunk Manifesto by Annalee Newitz



Kac goes Hopfengärtner

Apparently bioart allstar E.Kac features in his recent work methods employed by B.Hopfengärtner a couple of years ago ;) Eduardo Kac, Lagoglyphs: Lagoogleglyph I (2009) Google Earth work composed of Lagoglyph installed on the roof of Oi Futuro, Rio de Janeiro, approx. 26 x 56 ft; and custom-ordered WorldView2 satellite photograph.
Kac: http://www.ekac.org/oi_kac.show_overview.html
Hopfengärtner: http://hello.w0r1d.net/

Sidenote (Learning from the professionals): Always have female spectators in photographic representation of your artwork.




22.01.10 Preparation Workshop Heidelberg


iGEM 2009 Team Wash U: Synthetically Regulated Antenna Energy Production in Bioreactors

This group tries to grow a Alphaproteobacteria wich can be used for Energy Production with less energy wasted



iGEM 2009 Team Cambridge: E.chromi feat. Daisy Ginsberg + John King

<videoflash type="vimeo">7466044|400|300</videoflash>



DIYbio

Basierend auf das ArtScienceBangalore/Project des iGEM Wettbewerbs wurde eine kleine Forschung über "do-it-your-self" möglichkeiten im eigenen Atelier ein kleines Labor einzurichten mit dem man Biologie "hacken" kann. Bei der suche nach Informationen bin ich auf folgende Internetseiten gestoßen die sich damit befassen:

Eine Seite ist die Amateur-Bio-Hacker Seite DIYbio [11]

In der Stanford School of Medicine - Undersanding Genetics findet man Videos zu "Do-It-Yourself Strawberry DNA" [12]

Auf der nächsten Seite findet man interessante Artikel mit denen sich das ArtScienceBangalore Project befasst hat zu den Themen:

Art and Politics,Art,Science,Ethics,Design & Technology,Synthetic Biology,General Design Links usw. [13]

Wenn Salmonellen Leuchten!! Die OSAKA Gruppe präsentiert ihre Arbeiten.[14]




Synthetic Biology Software Suite (SynBioSS)

The Synthetic Biology Software Suite (SynBioSS) is a software suite for the generation, storing, retrieval and quantitative simulation of synthetic biological networks. The SynBioSS DS is a set of multiscale algorithms for modeling and simulating reaction networks, such as gene regulatory networks.



Spectacles - A visual editing framework

from the 2009 iGEM UC Berkeley Software Team Wiki

for the design of composite biological devices and the assignment of physical samples to functional concepts.