GMU:Synbio: Difference between revisions

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The more RNAs of the same type are present in a cell, the more proteins of the same type are made. So, if I do RNA sequencing, I get the information about the genes that are turned on or off, and I can even tell in which ratio that happenes. Biologists are talking about gene overexpression (= genes turned on at a higher level than normal) and underexpression (= genes turned on at a lower level than normal).

Unnormal gene expression is a typical indicator for a disregulation in a cell and can therefor be indicator for a disease. In many diseases the gene expression (and therefor the gene regulation) is unnormal.

Unnormal gene expression is a typical indicator for a disregulation in a cell and can therefor be indicator for a disease. In many diseases the gene expression (and therefor the gene regulation) is unnormal. But not only diseases lead to different gene expression: When you eat and drink, when you jump into cold water and in other situations gene expression might be altered.

Coming back to the point: Sequencing RNA from human blood is possible since some years. In the future, as automated sequencing gets better and cheaper, that could give us the oppotunity to have a sort of online-look onto our gene expression. We would simply take blood samples and put them into a full-automatic sequencer.

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 The more RNAs of the same type are present in a cell, the more proteins of the same type are made. So, if I do RNA sequencing, I get the information about the genes that are turned on or off, and I can even tell in which ratio that happenes. Biologists are talking about gene overexpression (= genes turned on at a higher level than normal) and underexpression (= genes turned on at a lower level than normal).
-Unnormal gene expression is a typical indicator for a disregulation in a cell and can therefor be indicator for a disease. In many diseases the gene expression (and therefor the gene regulation) is unnormal.
+Unnormal gene expression is a typical indicator for a disregulation in a cell and can therefor be indicator for a disease. In many diseases the gene expression (and therefor the gene regulation) is unnormal. But not only diseases lead to different gene expression: When you eat and drink, when you jump into cold water and in other situations gene expression might be altered.
 Coming back to the point: Sequencing RNA from human blood is possible since some years. In the future, as automated sequencing gets better and cheaper, that could give us the oppotunity to have a sort of online-look onto our gene expression. We would simply take blood samples and put them into a full-automatic sequencer.